- Rebecca Romijn as Roxanne Torcoletti. Based on the character Alexandra Spofford
- Lindsay Price as Joanna Frankel. Based on the character Jane Smart
- Jaime Ray Newman as Kat Gardener. Based on the character Sukie Rougemont
- Paul Gross as Darryl Van Horne. Based on the character Darryl Van Horne
- Sara Rue as Penny Higgins. Joanna's best friend.
- Ashley Benso as Mia Torcoletti. Roxie's teenage daughter and Josh's Girlfriend.
- Jon Bernthal as Raymond Gardener. Kat's husband and father to her five kids.
- Johann Urb as Will St. David. Joanna's and Kat's love interest.
- Veronica Cartwright as Bun Waverly. Local of the town who is also a Witch.
- Darren Criss as Josh. Mia's boyfriend and Chad's younger brother.
- Jack Huston as Jamie. Roxie's mysterious neighbor.
- Matt Dallas as Chad. Roxie's Deceased boyfriend and Josh's Older Brother.
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